CFTR and cystic fibrosis: Given that the actin cytoskeleton is a first‐responder to shear stress (Loufrani & Henrion, 2008) and facilitates the reformation of cells to align in the direction of flow (Osborn et al., 2006), a loss of CFTR activity could contribute to reduced endothelial barrier function observed in people with CF (Declercq et al., 2021) through altered actin dynamics and a loss of cellular alignment in response to flow.