Indeed, Choi et al. also reported that the elevation of hepatic miR-34a is related to the severity of NAFLD and reduced SIRT1 in the liver on account of targeting nicotinamide phosphoribosyltransferase (NAMPT) and, consequently, impairing NAD biosynthesis (Choi et al., 2013). Here, SIRT1 is linked to metabolic dysfunction-associated steatotic liver disease.