Upon hepatic insulin resistance, the content of diacylglycerol (DAG) leads to PKCε activation, which in turn plays a major role in binding to the IR and repressing its tyrosine kinase activity by Thr1160 phosphorylation (Monetti et al., 2007; Jornayvaz et al., 2011; Petersen et al., 2016; Lyu et al., 2020). Here, PRKCE is linked to Insulin resistance.