In particular, MFN2 has a direct role in lipid transfer, especially phosphatidylserine, between mitochondria and endoplasmic reticulum, prompting progression of liver diseases if depleted, as our findings in Apoe−/− HFD mice showed (Hernández-Alvarez et al., 2019; Joaquim and Escobar-Henriques, 2020). Here, APOE is linked to liver disorder.