SOX9 and colon adenocarcinoma: These hub genes to be further studied and get some significant achievements: (i) the low expression of the ARID1A in COAD tissue indicated poor COAD prognosis [3]; (ii) the up-regulation of the SOX9 facilitated the growth of colorectal carcinoma (CRC) cells for promoting CRC progression [4]; (iii) WTX loss is tightly associated with the CRC proliferation and liver metastasis [5]; and (iv) the high expression of TM4SF1 in CRC tissue enhances tumor proliferation, invasion, and migration [2].