It was very recently presented an association between bile acid‐receptors, such as nuclear farnesoid X receptors (FXRs),54, 55 and JAK/STAT3 in colon,56 which inspires a further exploration of FXRs possible expression in the hypopharynx and their potential interaction with JAK/STAT3 or other oncogenic pathways in bile reflux‐related HSCC. Here, NR1H4 is linked to bile reflux.