Specifically, STAT3 knockdown induced a strong suppression of total p‐STAT3 and Bcl‐2 protein levels, and significantly reduced STAT3 transcriptional activity and the transcriptional levels of anti‐apoptotic BCL2,32, 33 cancer and inflammatory‐related factors IL6, TNF‐α, RELA(p65), and STAT3,8, 11, 19, 26, 27, 33, 34, 35, 36, 37, 38 or cell proliferation and tumour promotion factors REL, EGFR, WNT5A and REL,36, 38, 39, 40 previously linked to BA‐induced oncogenic effect.4, 41. This evidence concerns the gene REL and cancer.