In the present study, we discovered that lnc‐UCA1 was positively correlated with Gensini score, TC, LDL‐C, and CRP in CHD patients, while miR‐26a and miR‐195 were negatively correlated with disease stenosis degree and some biochemical indexes in CHD patients, which could be explained as that (i) lnc‐UCA1 promoted oxidative stress and cell apoptosis in macrophage, which further accelerated the occurrence of atherosclerosis, therefore led to increased hyperlipidemia and advanced stenosis degree in CHD patients.17, 31. This evidence concerns the gene CRP and atherosclerosis.