Fan et al. demonstrated that selenocysteine (SeC) acted as a natural inhibitor of TrxR1 in vitro and in vivo to enhance AF‐induced human lung cancer cells killing through ROS‐mediated apoptosis and inactivation of Mitogen‐Activated Protein Kinase 1 (Erk) and Akt pathways.90 This evidence concerns the gene AKT1 and lung cancer.