Ito et al. proved that AF in combination with IPA‐3, an inhibitor of p21 activate kinase (PAK1) which is in turn regulated by PKCiota, had a highly synergistic effect in EGFR or KRAS mutant adenocarcinoma and squamous cell carcinoma cell lines and decreased tumor volume in mice models.99 Here, PAK1 is linked to atrial fibrillation.