TIMP1 and osteoporosis: Increased TIMP‐1 concentrations are indicative of an altered bone homeostasis, and associated with diseases like osteoporosis and rheumatoid arthritis (RA).30, 31, 32 None of the studies included in the current review reported that they defined osteoporosis, post‐menopausal woman (a group more susceptible to osteoporosis), and RA as exclusion factors.