MBNL1 and myotonic dystrophy type 1: Since DM1, which is associated with reduced MBNL1 activity, has been liked with mitochondrial changes (Ono et al. 1986; Gramegna et al. 2018), and MBNL1 is required for normal mitochondrial function in C2C12 cells (Yokoyama et al. 2020), it is likely that the loss of MBL-1 disrupts mitochondrial function [although mitochondrial genes are not enriched among differentially expressed genes in mbl-1(tm1563) mutants, Supplementary Table S4].