ICAM1 and Other metabolic disease: Metabolic disease elicits chronic inflammation, characterized by increased expression of adhesion molecules in the vascular endothelium and accumulation of inflammatory cells in the tissue.26 We compared the expression of the vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) on the endothelial surface of coronary arteries and venules in WT and KO mice under HFHS or CTD by immunohistochemistry.