In the Copenhagen City Heart Study, which included 10 261 participants, two common CETP gene polymorphisms reducing CETP activity were associated with significant reductions in the risk of ischaemic heart disease, myocardial infarction (MI), ischaemic cerebrovascular disease, and ischaemic stroke.31 In addition, it was shown that the number of alleles with gene polymorphisms determined the impact on ASCVD risk. The gene discussed is CETP; the disease is ischemic stroke.