APC and malignant colon neoplasm: A connection of tumors with colon inflammation is supported by the fact that the mutational landscape of inflammation-induced colon cancer differs from the majority of sporadic colon tumors, which typically harbor mutations in APC or Ctnnb1 (Guinney et al., 2015; Network CGA, 2012; Robles et al., 2016; Sanchez-Vega et al., 2018).