To assess the potential role of Wnt ligands in CRC, we analyzed the data from patients who do not harbor mutations in one of following core components of the Wnt pathway: APC, CTNNB1, RNF43, ZNRF3, TCF7L2 (TCF4), FZD1, FZD3, DKK3, and LRP6. This evidence concerns the gene LRP6 and colorectal carcinoma.