As summarized in Table 4, of the 46 CNS proteins homologous to TSH-R, 5 (11%; LGR4, chondroadherin, alpha-1A adrenergic receptor, Mu opioid receptor, and melanin-concentrating hormone receptor 1) were reported to stimulate autoAb, and in the following conditions: CNS demyelinating disease, autoimmune hepatitis, refractory hypertension, psychiatric disorders, chronic fatigue syndrome and vitiligo [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51]. This evidence concerns the gene LGR4 and demyelinating disease of central nervous system.