In this study, the gliosarcoma IDH-wildtype had two TP53 mutations (p.Arg248Trp, c.742 C>T and p.Val173Leu, c.517 G>T) and NF1 mutation (splicing, c.1185+1 G>T and p.Pro1421Gln, c.4262 C>A), and PDGFRA amplification; however, neither PTEN mutation nor CDKN2A deletion was present. This evidence concerns the gene TP53 and gliosarcoma.