Our Lynch syndrome patients had a germline MSH2 mutation (p.Tyr405*/c.1215 C>A) and MSH6 mutation (p.Ser602*/c1805C>G, p.Arg1334Gln/c.4001 G>A, p.Phe1088fs/c.3261dupC, p.Gln889fs/c.2665dupC), which have previously been reported in a Lynch syndrome patients29,36. Here, MSH6 is linked to Lynch syndrome.