TIMP1 and colorectal carcinoma: Although our study have provided evidence that SNP rs2682818 is involved in CRC progression by affecting the expression of miR-618, and it also have proved that miR-618 regulate the progression of CRC via modulating the expression level of TIMP1, the signal pathways downstream of miR-618-TIMP1 signal axis are still not very clear, we will continue to explore the deeper molecular mechanisms.