Table 5 below shows that there is a significant linear correlation between soluble ADAM33 levels and ADAM33 mRNA expression with soluble MMP-9 levels in COPD patients through the Spearman Correlation test (P < 0.001), so the higher the soluble ADAM33 level, the higher the soluble MMP-9 level. The gene discussed is ADAM33; the disease is chronic obstructive pulmonary disease.