In Fig. 8B shows ADAM33 levels (ng/ml) and GOLD COPD stage I to IV in COPD and non-COPD patients tend to be lower, except for the average ADAM33 levels in GOLD COPD stage II which tends to be lower when associated with the average ADAM33 levels in GOLD COPD stage III. This evidence concerns the gene ADAM33 and chronic obstructive pulmonary disease.