The mRNA levels of ADAM33 were significantly higher in COPD patients (10.39 ± 1.76 fold change; 95% confidence interval (CI) 9.802–10.981) as compared to that in non-COPD individuals (6.93 ± 0.39 fold change; 95% CI 6.780–7.079; P < 0.001; Fig. 1). The gene discussed is ADAM33; the disease is chronic obstructive pulmonary disease.