Significant positive correlations between LINE-1 and type I IFNs were detected in DM samples (IFN-α2, ρ = 0.895, P < 0.0001; IFN-β1, ρ = 0.965, P < 0.0001), SLE samples (IFN-α2, ρ = 0.993 P < 0.0001; IFN-β1, ρ = 0.963, P < 0.0001), and AIBD samples (IFN-α2, ρ = 0.939, P < 0.0001; IFN-β1, ρ = 0.943, P < 0.0001). This evidence concerns the gene IFNA2 and systemic lupus erythematosus.