Although analysis of the effects of knocking out or knocking down RDH14 on neuronal differentiation and maturation was not feasible, as it is difficult to predict the effects of lack of retinol dehydrogenase 14 enzyme when utilizing retinoic acid as the standard differentiation agent on neuroblastoma cell lines, we were able to effectively knock-down expression of endogenous RDH14 in SK-N-SH cells. Here, RDH14 is linked to neuroblastoma.