Although reports indicate RDH14 is expressed in microsomes10, our own data using over-expression of an RDH14-GFP construct (in HEK293 cells and SK-N-SH neuroblastoma cells, as well as data from The Human Protein Atlas (http://www.proteinatlas.org) using antibodies against endogenous RDH14 in A-431 (squamous carcinoma) and U-2-OS (osteosarcoma) cells, suggest that RDH14 protein is also strongly expressed in the nucleoplasm (Fig. 2). The gene discussed is RDH14; the disease is neuroblastoma.