At an R2 of around 0.04 in men and 0.03 in women, the UK Biobank has 0.8 power to detect an odds ratio (OR) of 0.91 for IHD per one standard deviation increase in SHBG in men and an OR of 0.86 for IHD in women54. Here, SHBG is linked to myocardial ischemia.