We replicated using 3 SNPs (rs12150660, rs1625895 and rs1641537) in SHBG. In the UK Biobank we identified 25,409 IHD cases in 179,911 white British men and 12,511 IHD cases in 212,074 white British women (Supplementary Table S1). Here, SHBG is linked to myocardial ischemia.