As compared to Controls, the percentage change for the absolute number of CD19 + B-cells was 5.7% lower following HIIT (Fig. 4A: 95% CI [− 38.8, 27.2], g = 0.21), while the absolute number of CD19+/CD5 + CLL-cells was 21.4% lower following HIIT (Fig. 4B: 95% CI [− 80.7, − 37.9], g = 1.21), and the frequency of CD19 + /CD5 + CLL-cells was 19.2% lower following HIIT (Fig. 4C: 95% CI [− 40.0, 1.6], g = 0.54). The gene discussed is CD5; the disease is B-cell chronic lymphocytic leukemia.