We found that insomnia-fever-rash symptom cluster includes the cytokines (e.g., IL6, IL10, and IL1B) and inflammatory biomarkers (e.g., PIK3R1, STAT3, and TNF) as the hub genes in their associated PPI network and tends to be related to the inflammatory immune-related insomnia subtype involving the biological processes, such as B-cell differentiation, antigen processing and presentation, and cytokine-mediated signaling pathway (Fig. 7 and Table 4). This evidence concerns the gene IL1B and insomnia.