For HNSCC, 8/57 (14%) integration loci were associated with W12 super-enhancers and 62.5% of these loci overlapped integration hotspots profiled in CESC, including the KLF5/KLF12, MYC, ERBB2, and VMP1 gene loci. Here, MYC is linked to head and neck squamous cell carcinoma.