KLF5 and cancer: Furthermore, several cancer driver genes, including ASXL1, CACNA1A, IRF6, KANSL1, KLF5, KRT222, MYC, PPM1D, PTCH1, and PTPDC156 were located within 1 Mb of super-enhancers that overlapped with integration hotspots (Supplementary Fig. 5 and Supplementary Data Table 17).