To further explore how SKOR1 participates in the regulation of T2D, a protein interaction prediction tool (http://string-db.org) was used to assess that SKOR1 interacts with multiple proteins, such as ladybird homeobox 1 (LBX1) and SMAD family member 6 (SMAD6) (Fig. 5a). Here, SMAD6 is linked to type 2 diabetes mellitus.