HGF and hepatocellular carcinoma: However, there were noticeable alterations in mitochondrial morphology: HGF triggered extensive mitochondrial fragmentation in HCC cells (Fig. 3a), resulting in decreased median branch length and increased numbers of individual mitochondria (Fig. 3b), without affecting mitochondrial activity or mitochondrial mass, as measured by tetramethylrhodamine ethyl ester and MitoTracker Green (Supplementary Fig. S1d), suggesting that Met might play an important role in the regulation of mitochondrial dynamics.