Y38 phosphorylation could abolish Fis1 N-terminal negative structure so that Drp1 binding increased with Fis1.44 By IHC staining of liver cancer tissues, we also confirmed that p-Fis1 was a good predictor of recurrence and overall survival of patients with HCC, and high expression of p-Fis1, as well as HGF, was positively associated with poor prognosis. Here, DNM1L is linked to hepatocellular carcinoma.