CDC42 and neoplasm: Signaling by the RAS/MAPK and PI3K/AKT pathways reaches the nucleus to affect gene expression related to angiogenesis, invasion, and metastasis.54,55 Cytoplasmic signaling cascades mediated by RAC1/CDC42 and PAK elicit cytoskeletal changes for cell motility.56,57 Signals through the RAP1 and RAC1/CDC42 pathways reach the plasma membrane and control cadherin and integrin adhesion molecules and thereby affect cell migration.57,58 Our study further improved the downstream regulation network of Met in tumor metastasis.