High expression of HGF or p-Fis1 (Y38) was correlated with shorter tumor-free interval; the median tumor-free interval in patients with low HGF expression was 59.17 months, while in patients with high HGF expression, it was only 49.19 months (Fig. 7d); the median tumor-free interval in patients with low p-Fis1 (Y38) expression was 48.29 months, while in patients with high p-Fis1 (Y38) expression, it was only 28.58 months (Fig. 7f). This evidence concerns the gene FIS1 and neoplasm.