Dynamin-like protein 1 (DnmL1; Drp1) is key mitochondrial fission executing protein that is recruited to form a ring at the mitochondrial outer membrane to contract the mitochondrial transverse diameter via ring constriction by GTPase activity.43 Dysregulation of Drp1 has been reported to contribute to tumor growth, metastasis, and chemoresistance.29,35 After HGF treatment, we assessed mitochondrial localization of Drp1 and found that HGF significantly stimulated Drp1 expression in isolated mitochondrial fractions (Fig. 3c). This evidence concerns the gene HGF and neoplasm.