TSHR and hypothyroidism: Interestingly, McLachlan et al. found that by depletion of T regulatory cells (Treg) with anti-CD25 before TSHR-Ad immunization, the immunization with TSHR-Ad induced extensive thyroid lymphocytic infiltration and hypothyroidism in human TSHR A subunit-expressing transgenic mice (named Lo-expressor TSHR A subunit transgenic mice) but not in these mice without Treg depletion.