AMD disease grading, like explained before [42] (1 = physiological retina, 2 = 1–14 DRS, 3 = 15–100 DRS, 4= > 100 DRS, 5 = any number of DRS plus signs of late AMD), revealed a mean of grade 2.6 +/− 0.6 in NRF2−/− and 1.7 +/− 0.6 in ApoE−/− mice. Here, NFE2L2 is linked to age-related macular degeneration.