In addition, studies have shown that SIRT3 can protect the mitochondria against oxidative damage by regulating FOXO3 deacetylation, and the mitochondrial oxidative stress and mtDNA damage in osteoblasts can be induced by inhibiting the SIRT1-FoxO3a-MnSOD pathway in osteoporosis [26–28]. Here, FOXO3 is linked to osteoporosis.