PDGFC and neoplasm: PDGF-C activity must be tightly controlled, and uncontrolled PDGF-C expression has been reported to be associated with numerous pathological conditions, such as choroidal neovascularization [95], chronic myocarditis [96], glomerulosclerosis [64], tissue fibrosis [12,15,97–99], atherosclerosis [100] and various tumours [11,98,101–106].