Compared to non-DM, patients with DM were obese (31.4 [28.0, 35.6] vs 27.8 [23.6, 30.3] kg/m2, p = 0.003), took longer time to reach TG-50% (16.0 [10.5, 27.0] vs 9.5 [5.3, 14.8] hours, p = 0.004) and TG-goal (41.0 [25.0, 60.5] vs 14.5 [12.5, 25.5] hours, p = 0.000) since starting CII and had higher daily insulin need (1.7 [1.3, 2.1] vs 1.1 [0.5, 1.9] U/kg/day, p = 0.041). This evidence concerns the gene INS and diabetes mellitus.