In bivariate analysis and binary logistic regression, compared to SRP with DM, RRP with DM showed higher total daily insulin use (U/kg/day) (1.9 [1.4, 2.3] vs 1.6 [1.1, 1.8], OR 4.6, CI 1.4–15.3, p = 0.019). This evidence concerns the gene INS and diabetes mellitus.