According to the results, IL-1β expression levels were increased with 10, 100 ng / ml and 1 μg / ml LPS or CFS in combination with 10 ng / ml IFN-ɣ 1.64, 3.21, 1.83 and 3.16, 2.14, 2.17 fold for IL-1β; 1.55, 1.41, 0.82 and 4.42, 3.62, 5.18 for TNF-α; 3.07, 3.88, 13.64 and 10.23, 32.72, 4.34 for IL-8, respectively compared to the control group (Fig 2). Here, IL1B is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.