The salient results of the present study are as follows: (i) low MPV at baseline is an independent predictor of early and late bleeding events following TAVR; (ii) this effect is independent of the extent of platelet P2Y12 inhibition and HMW-multimers defect of vWF; (iii) no impact of MPV on thrombotic events including stroke and myocardial infarction could be evidenced. This evidence concerns the gene P2RY12 and Stroke.