RAP2A and obesity due to melanocortin 4 receptor deficiency: Consistent with these findings, data (Type Two Diabetes Knowledge Portal; https://t2d.hugeamp.org/) from hundreds of human sequencing studies demonstrates clear correlations between gene polymorphisms in ADRB3, RAP2A, or TRIB1 and anthropometric factors, such as weight, obesity, BMI, waste-hip ratio, plasma lipid levels, and type 2 diabetes.