AFP and Cirrhosis: A total of 173,378 high-risk patients with chronic liver disease (cirrhosis) in Japan were screened by ultrasound combined with AFP, AFP-L3, and PIVKA-II every 3–4 months, and the extremely high-risk population was screened by Gd-EOB-DTPA-enhanced MRI or multi-slice spiral CT every 6–12 months.