DNA methylation patterns can differentiate NF2-mutant from non-NF2 mutant tumors, with further differentiation of non-NF2 mutant tumors into atypical versus “benign.” In de novo formation of atypical NF2-mutant meningiomas, hypermethylation is either associated with large-scale CNVs, or gained due to SMARCB1 co-mutations [20]. Here, SMARCB1 is linked to meningioma.