POMC and thyroid gland disorder: During pregnancy follow-up, 4 patients had to initiate treatment for a de novo deficit: one for thyroid deficit (T4 7.5 pmol/L; reference range 9–19 pmol/L) at 32 weeks, one for ACTH at 24 weeks (sinusitis in a patient with prepregnancy partial deficit) and 2 patients for ADH deficit at 18 and 21weeks (diuresis 2860 mL/24 h and 5200 mL/24 h) respectively.