Sixteen months after delivery and 2 months after stopping partial breastfeeding she initiated transdermal hormone therapy due to hypogonadotropic hypogonadism (estradiol 0.13 nmol/l, LH 7.9 IU/L, FSH 6.6 IU/L) with normal prolactin and severe vasomotor symptoms. This evidence concerns the gene PLOD1 and hypogonadotropic hypogonadism.