In contrast, the switch from branched core 2 to Gal-4-binding core 1 mucin-type O-glycans, to which the 3′-O-sulfated disaccharide suTF antigen (CD176su) belongs, has been reported to drive metastatic castration-resistant prostate cancer (Tzeng et al. 2018) and to exacerbate intestinal inflammation induced by Gal-4 (but not Gal-3) in CD4+ intestinal T cells by stimulating interleukin-6 (IL-6) production (Hokama et al. 2004; Nishida et al. 2012). The gene discussed is LGALS4; the disease is Familial prostate cancer.