We collected and analyzed a 45 hr dataset of male-male social interactions using mice from five different lines: three lines that genocopy autism-associated mutations (Chd8 [Katayama et al., 2016], Cul3 [Dong et al., 2020], and Nlgn3 [Tabuchi et al., 2007]), one inbred line that has previously been shown to exhibit atypical social behavior and is used as an autism ‘model’ (BTBR [Hong et al., 2015]), and a C57Bl/6J control line. The gene discussed is CHD8; the disease is autism.