IL18 and acute kidney injury: Due to the limitations present in conventional markers, non-traditional biomarkers (such as NGAL, IL-6, IL-18, KIM-1, L-FABP, TIMP-2, IGFBP7, syndecan-1, and nephrin) have become a necessity in the early diagnosis of AKI in newborns with sepsis, so that death rates, length of hospitalization, and the incidence of future complications are decreased.