In cases of neonatal sepsis, Fan and Yu (2012) did not recommend the isolated use of inflammatory markers CRP, PCT, interleukin-8 (IL-8), TNF-α and interleukin-1 beta (IL-1β); although IL-6 was rated as superior in relation to the majority of markers, it should not be used in isolation37. This evidence concerns the gene IL1B and Neonatal sepsis.