As for the Breast Invasive Ductal Carcinoma (with 996 cases), which 90 cases (9.04%) involved in genetic alternations of SKA1/2/3 [3 cases (0.3%) of mutation, 1 case (0.1%) of structural variant, 74 cases (7.43%) of amplification, 10 cases (1%) of deep deletion, 2 cases (0.2%) of multiple alterations] (Figure 5(a)). Here, SKA1 is linked to medical procedure.