TLX2 and brain ischemia: All these compounds have been screenedwith several approaches moving from functional high-throughput screeningto patch-clamp electrophysiology and Fura-2AM video-imaging on single-cells.Furthermore, the most selective derivatives have been tested in twodifferent in vitro models of brain ischemia on primary cortical neurons.Computational studies combined with experimental data allowed us toproduce the first prototypal model for the design of new molecularentities acting on NCX proteins.