Mutations in WT1 can cause many different diseases including non‐syndromic POI and syndromic POI such as Denys–Drash syndrome (Wang et al., 2018), WAGR syndrome (Huynh et al., 2017), and Frasier syndrome (Barbaux et al., 1997; Klamt et al., 1998). This evidence concerns the gene WT1 and Frasier syndrome.