Human chromosome 1p36 is a region rich in tumor suppressor genes, and heterozygosity deletion in this region has been observed in a variety of human malignant tumors including lung, breast, stomach, colorectal, endometrial, and ovarian cancers, sarcoma, etc.17In our previous study we explored the region 1p36 in ESCC and found a new tumor suppressor gene retinoblastoma protein which binds to the zinc finger gene 1 (RIZ1). Here, PRDM2 is linked to cancer.