In human ESCC tissues the positive expression of Mig‐6 protein was 26.7% (24/90), while the positive expression of Mig‐6 protein in corresponding normal esophageal epithelial tissues was 61.1% (55/90), with statistical difference (χ2 = 21.679,p < 0.05). Here, ERRFI1 is linked to esophageal squamous cell carcinoma.