In ICC, a variety of ion channels have been reported, including transient receptor potential (TRP) channels,4 Ca2+‐activated Cl− channels,5 voltage‐dependent Ca2+ channels,6, 7 voltage‐dependent K+ channels,8 ERG channels,9 Na+ channels10 and ATP‐sensitive K+ channels.11, 12. This evidence concerns the gene CA2 and intrahepatic cholangiocarcinoma.