As xenograft mouse models cannot fully mimic the complex microenvironment of lung cancer initiation and development in vivo, we next established a GEM model with lung‐specific doxycycline‐inducible EML4‐ALK expression to further evaluate the activity of XMU‐MP‐5 in vivo (Soda et al, 2008; Chen et al, 2010, 2014). This evidence concerns the gene ALK and lung cancer.