NLGN3 and autism: Furthermore, Nlgn3 knockout (KO) rats and mice, as well as mice with an autism-associated Nlgn3 mutation, exhibit ASD-related behavioral abnormalities such as reduced sociability [9–11], impaired social memory [10, 12, 13], decreased vocalization [12, 14], increased repetitive behaviors [13, 15, 16], and hyperactivity [9, 12, 13, 16].