IL-36 and IL-36R were both found elevated in the synovium in RA patients and RA-inducing animal models, with the ability to activate IL-6 and IL-8 secretion in RA-FLS [17, 18], while the molecular mechanism of IL-36 in RA pathology remains to be studied. The gene discussed is CXCL8; the disease is rheumatoid arthritis.