Correspondingly, we observed increased expression levels of PD-1 in the T cells of WCL-vaccinated mice, which is associated with AML immune-suppression [50, 51] and is a mechanism of immune evasion in C1498 cells [52], suggesting that AMCNP vaccination might be beneficial in preventing immune evasion during AML relapse. The gene discussed is PDCD1; the disease is acute myeloid leukemia.