Toll-like receptor 5 (TLR5), one of the PRRs against flagellin, was shown to play a crucial role in mediating the response of split-virus vaccines such as TIV influenza vaccine and IPOLTM, a purified viral subunit vaccine against polio similar to TIV in regards to being an purified viral subunit vaccine3. The gene discussed is TLR5; the disease is poliomyelitis.