Data from both in vitro and in vivo experiments indicated that GC-secreted exo-lncFERO upregulated the expression of SCD1 in GCSCs by binding with SCD1 mRNA and recruiting heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), leading to suppressed ferroptosis in GCSCs and the decreased chemosensitivity of gastric tumors. The gene discussed is SCD; the disease is gastric neoplasm.