In this study, we identified a novel network mediated by exosomes that regulates ferroptosis and stemness of GCSC, in which exo-lncFERO derived from GC cells regulates SCD1 protein expression with the assistance of hnRNPA1, resulting in decreased content of polyunsaturated fatty acids, suppressed ferroptosis, and advanced stemness in GCSC. Here, SCD is linked to gastric cancer.