CASP1 and myocardial ischemia: Compared with sham group, mice exposed to 45 min myocardial ischemia followed by 60, 120 or 180 min reperfusion showed significantly higher pro-caspase-1, cleaved caspase-1, pro-caspase-11 and cleaved caspase-11 protein expression in the heart, and the expression increased with reperfusion time (Fig. 1A).