UBE2E3 and endocrine system disorder: Network 1 (IPA® score 67) was annotated to endocrine system disorders, gastrointestinal disease, and immunological disease, and identified H4 clustered histone 1 (H4C1), histone h3, and E3 ubiquitin-protein ligase (RBX1) as nodes with the highest number of network connections (Fig. 3, Supplementary Table 8).